This paper traces binational collaborative efforts between academics from Mexico and the United States. During the Salinas de Gortari Presidency, Programa para las Comunidades Mexicanas en el Extranjero (Program for Mexican Communities Abroad) was established. As a result, academics from both countries cooperated on a series of initiatives that addressed issues pertaining to Latinos in higher education in both countries. Researchers focused on health, immigration, history, culture, bilingual education, language, applied research, environmental justice, and other topics. These binational initiatives involved research institutions and universities alike and culminated with the resolution of El Plan de San Luis Potosi that called for the establishment of an international organization of higher education institutions and scholars in North America.