Using data from the 2007–2009 Annual Social and Economic (ASEC) supplement of the Current Population Surveys (CPS), this study explores the relationship between poverty and the health of children from various racial/ethnic minority and immigrant families in the Midwest. Findings show that: (1) Racial/ethnic minority children experience poorer health than Non-Hispanic White children; (2) Increased poverty among children predicts poorer children’s health; and (3) Immigrant children have poorer health than native-born counterparts, and second-generation immigrant children have poorer health than first- and third-generation immigrant children. This study demonstrates the health disadvantages of children from racial/ethnic minority families faced with poverty in the Midwest. The gap in children’s health between Non-Hispanic White and minority children persists even after accounting for the effects of immigrant status, poverty, family structure, parental education, health insurance coverage, and metropolitan/nonmetropolitan residence. Improving the economic well-being of all racial/ethnic minority and immigrant families would improve children’s health.